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KMID : 0043320070300060670
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Archives of Pharmacal Research
2007 Volume.30 No. 6 p.670 ~ p.673
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New Amide N-glycosides of Ansamitocins Identified from Actinosynnema pretiosum
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Ma Juan
Zhao Pei-Ji
Shen Yue-Mao
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Abstract
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By using preparative TLC as the critical isolation procedure, two compounds, including one new amide N-glycosides of ansamitocin (2), were isolated from Actinosynnema pretiosum. The compounds were elucidated as N-demethyl-N-β-D-glucopyranosyl ansamitocin P-2, named ansamitocinoside P-2 (1), and N-demethyl-N-β-D-glucopyranosyl ansamitocin P-1, named ansamitocinoside P-1 (2) on the basis of their spectral data. The 1H-NMR and 13C-NMR assignments were made for 1 and 2 while the 13C-NMR assignment for 1 was revised. Bioassay results showed that 1 had antineoplastic activity.
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KEYWORD
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Actinosynnema pretiosum, Ansamitocin, Ansamitocinoside, Antineoplastic activity
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